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| Also known as:
| Also known as:
|'''Gastroduodenal ulceration<br>
|'''Gastroduodenal ulceration<br>
'''Gastrointestinal ulceration<br>
'''Equine Gastric Ulcer Syndrome<br>
'''Equine Gastric Ulcer Syndrome<br>
'''Peptic ulcer disease<br>
'''Peptic ulcer disease<br>
==Description==
==Description==
The term '''Equine gastric ulcer syndrome (EGUS)''' is used to describe the disease complex associated with ulceration of the oesophageal, gastric or duodenal mucosa (EGUC) in horses. When such damage is caused by acidic gastric juice, the defect is described as a '''peptic ulcer''' (EGUC). Ulceration of either or both (2 in Sanchez) regions of the gastric mucosa is one of the most important conditions of the equine stomach as it may limit performance (Bell, R.J, Mogg, T., Kingston, J.K (2007) Equine gastric ulcer syndrome in adult horses: a review. ''N Z Vet J'', 55(1):1-12). and compromise welfare (Martineau 2009). The non-glandular (proximal or orad) region of the equine stomach is lined by stratified squamous mucosa and a glandular mucosa lines the distal (aborad) portion. The two regions meet abruptly at the '''''margo plicatus''''' (Sanchez), adjacent to where most ulcers occur (EGUC). Damage to these regions occurs via differing pathophysiological routes and varies in severity from inflammation, to cellular death and sloughing causing disruption of the superficial mucosa ('''erosion'''), penetration of the submucosa down to the level of the ''lamina propria'' (EGUC)('''ulceration'''), full thickness ulceration ('''perforation''') (Sanchez) and potentially duodenal stricture (Merck). The occult nature of the disease typically precludes the observation of clinical signs until severe ulceration has developed.(EGUC)
==Prevalence==
==Prevalence==