Changes

===NSAIDs===

===NSAIDs===

As in [[Gastric Ulceration - all species|other species]], nonsteroidal anti-inflammatory drugs (NSAIDs)have been shown to cause gastric ulcers in horses. Typicaly this is associated with high doses or frequent administration of phenylbutazone or flunixin meglumine.  However, although there is evidence to the contrary,<ref>Andrews, F.M, Reinemeyer, C.R, Longhofer, S.L (2009) Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses. ''Vet Ther'', 10(3):113-20.</ref>therapeutic doses of NSAIDs may be sufficient to induce EGUS.  Other studies have suggested that suxibuzone causes significantly less ulcerogenic effects than phenylbutazone when administered orally(Monreal et al. 2004) and that combination treatment with phenylbutazone and flunixin meglumine may be more risky than phenylbutazone alone.(Reed et al. 2006)  The ulcers produced by NSAIDs are unusual in that they have a predilection for the glandular mucosa(MacAllister et al. 1993 in Jonssen)(Furr and Murray 1989; Kuinaran and Bhuvanakumar 1994 in Vatisats 2 1999), they may look different endoscopically from ulcers that occur naturally,(Jonssen 2006) and they appear to heal spontaneously.(Jones 1983; MacAllister and Sangiah 1993 in Vatisats 2 1999)  Despite the well-established link bewteen NSAIDs and ulcers, NSAIDs are rarely responsible for the lesions in horses in race training.(Vatistas et al. 3994b; Murray et al. 1996; Vatistas 1998 in Vatistas 2 1999)  

As in [[Gastric Ulceration - all species|other species]], nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to cause gastric ulcers in horses. Typicaly this is associated with high doses or frequent administration of phenylbutazone or flunixin meglumine.  However, although there is evidence to the contrary,<ref>Andrews, F.M, Reinemeyer, C.R, Longhofer, S.L (2009) Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses. ''Vet Ther'', 10(3):113-20.</ref>therapeutic doses of NSAIDs may be sufficient to induce EGUS.  Other studies have suggested that suxibuzone causes significantly less ulcerogenic effects than phenylbutazone when administered orally(Monreal et al. 2004) and that combination treatment with phenylbutazone and flunixin meglumine may be more risky than phenylbutazone alone.(Reed et al. 2006)  The ulcers produced by NSAIDs are unusual in that they have a predilection for the glandular mucosa(MacAllister et al. 1993 in Jonssen)(Furr and Murray 1989; Kuinaran and Bhuvanakumar 1994 in Vatisats 2 1999), they may look different endoscopically from ulcers that occur naturally,(Jonssen 2006) and they appear to heal spontaneously.(Jones 1983; MacAllister and Sangiah 1993 in Vatisats 2 1999)  Despite the well-established link bewteen NSAIDs and ulcers, NSAIDs are rarely responsible for the lesions in horses in race training.(Vatistas et al. 3994b; Murray et al. 1996; Vatistas 1998 in Vatistas 2 1999)

===Temperament===

===Temperament===