Changes

==Roles in the Body==

==Roles in the Body==

Histidine is present at high concentrations in haemoglobin; the positive charge on the imidazole side chain of this amino acid promotes oxygen exchange in the lungs and other tissues<ref>Cianciaruso B, et al. Histidine, an essential amino acid for adult dogs. J Nutr 1981;111:1074-1084.</ref>.

Histidine is present at high concentrations in haemoglobin; the positive charge on the imidazole side chain of this amino acid promotes oxygen exchange in the lungs and other tissues<ref>Cianciaruso B, et al. Histidine, an essential amino acid for adult dogs. J Nutr 1981;111:1074-1084.</ref>.

'''Histamine a neuro-active compound is formed from the decarboxylation of histidine, and plays a role in immune function and vasodilation'''. '''Carnosine is a histidine derived dipeptide that acts as a cellular antioxidant and copper and zinc chelator within mammalian cells'''<ref>Boldyrev AA, et al. Physiology and pathophysiology of carnosine. Physiol Rev 2013;93:1803-1845.</ref>.

'''Histamine a neuro-active compound is formed from the decarboxylation of histidine, and plays a role in immune function and vasodilation'''. '''Carnosine is a histidine derived dipeptide that acts as a cellular antioxidant and copper and zinc [[Nutrition Glossary#Chelator|chelator]] within mammalian cells'''<ref>Boldyrev AA, et al. Physiology and pathophysiology of carnosine. Physiol Rev 2013;93:1803-1845.</ref>.

==Consequences of Histidine Deficiency==

==Consequences of Histidine Deficiency==