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* Foetal ovaries produce oestradiol, but this does NOT defeminize the [[Hypothalamus_-_Anatomy_%26_Physiologyhypothalamus]].
 
* Foetal ovaries produce oestradiol, but this does NOT defeminize the [[Hypothalamus_-_Anatomy_%26_Physiologyhypothalamus]].
* A protein called alpha-fetoprotein binds oestradiol to prevent it from crossing the blood brain barrier, therefore oestradiol cannot effect the [[hHypothalamus_-_Anatomy_%26_Physiologyypothalamus]].
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* A protein called alpha-fetoprotein binds oestradiol to prevent it from crossing the blood brain barrier, therefore oestradiol cannot effect the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
 
* Alpha-fetoprotein is synthesized firstly by the embryonic yolk sac and then by the foetal liver.
 
* Alpha-fetoprotein is synthesized firstly by the embryonic yolk sac and then by the foetal liver.
 
* Alpha fetoprotein functions as:
 
* Alpha fetoprotein functions as:
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** Carrier of fatty acids
 
** Carrier of fatty acids
 
* As GnRH surges, LH and Oestradiol surge ~ every 20 days in the female.
 
* As GnRH surges, LH and Oestradiol surge ~ every 20 days in the female.
** Surge frequency varies between species, dependent on the length of their oestrous cycles.
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** Surge frequency varies between species, dependent on the length of their [[Female_Reproductive_Tract_-Oestrous_Cycle_-_Anatomy_%26_Physiology|oestrous cycles]].
 
* Between surges, there are low amplitude LH pulses.
 
* Between surges, there are low amplitude LH pulses.
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