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* Foetal ovaries produce oestradiol, but this does NOT defeminize the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
 
* Foetal ovaries produce oestradiol, but this does NOT defeminize the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
* A protein called alpha-fetoprotein binds oestradiol to prevent it from crossing the blood brain barrier, therefore oestradiol cannot effect the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
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* A protein called alpha-fetoprotein binds oestradiol to prevent it from crossing the [[Blood_Brain_Barrier_%28BBB%29|blood brain barrier]], therefore oestradiol cannot effect the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
 
* Alpha-fetoprotein is synthesized firstly by the embryonic yolk sac and then by the foetal liver.
 
* Alpha-fetoprotein is synthesized firstly by the embryonic yolk sac and then by the foetal liver.
 
* Alpha fetoprotein functions as:
 
* Alpha fetoprotein functions as:
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