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{{toplink
 
{{toplink
|backcolour =EED2EE
   
|linkpage =Reproductive System - Anatomy & Physiology
 
|linkpage =Reproductive System - Anatomy & Physiology
 
|linktext =Reproductive System  
 
|linktext =Reproductive System  
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|pagetype =Anatomy
 
|pagetype =Anatomy
 
|sublink1=Reproductive System - Anatomy & Physiology#Puberty
 
|sublink1=Reproductive System - Anatomy & Physiology#Puberty
|subtext1=PUBERTY
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|subtext1=Puberty
 
}}
 
}}
 
<br>
 
<br>
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== Defeminizing the Hypothalamus in the Male ==
 
== Defeminizing the Hypothalamus in the Male ==
   −
* Testosterone crosses the [[Blood_Brain_Barrier_%28BBB%29|blood-brain barrier]] and is converted into oestradiol.
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* Testosterone crosses the [[Blood Brain Barrier - Anatomy & Physiology|blood-brain barrier]] and is converted into oestradiol.
 
* In the brain, oestradiol 'defeminizes' the [[Hypothalamus_-_Anatomy_%26_Physiology|hypothalamus]].
 
* In the brain, oestradiol 'defeminizes' the [[Hypothalamus_-_Anatomy_%26_Physiology|hypothalamus]].
 
* Surge centre function is minimized.
 
* Surge centre function is minimized.
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* Foetal ovaries produce oestradiol, but this does NOT defeminize the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
 
* Foetal ovaries produce oestradiol, but this does NOT defeminize the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
* A protein called alpha-fetoprotein binds oestradiol to prevent it from crossing the [[Blood_Brain_Barrier_%28BBB%29|blood brain barrier]], therefore oestradiol cannot effect the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
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* A protein called alpha-fetoprotein binds oestradiol to prevent it from crossing the [[Blood Brain Barrier - Anatomy & Physiology|blood brain barrier]], therefore oestradiol cannot effect the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]].
 
* Alpha-fetoprotein is synthesized firstly by the embryonic yolk sac and then by the foetal liver.
 
* Alpha-fetoprotein is synthesized firstly by the embryonic yolk sac and then by the foetal liver.
 
* Alpha fetoprotein functions as:
 
* Alpha fetoprotein functions as: