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− | {{review}}
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| <br> | | <br> |
| <p>''Shortened to IgD''</p> | | <p>''Shortened to IgD''</p> |
− | [[Image:LH IgD.png|thumb|150px|right|'''IgD''']] | + | |
− | [[Image:IgD.jpg|thumb|right|150px|IgD - B. Catchpole, RVC 2008]] | + | [[Image:LH IgD.png|thumb|250px|right|'''IgD''']] |
− | <p>IgD is present in ruminants, pigs, (dogs) and rodents but has not been identified in horses, cats, rabbits and chickens. It is mainly expressed on the surface of B-cells i.e. it is never secreted.</p>
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| + | [[Image:IgD.jpg|thumb|right|250px|IgD - B. Catchpole, RVC 2008]] |
| + | |
| + | ==Overview== |
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| + | IgD is present in ruminants, pigs, dogs and rodents but has not been identified in horses, cats, rabbits and chickens. It is mainly expressed on the surface of B-cells i.e. it is never secreted. |
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| ==Structure== | | ==Structure== |
− | <p>IgD is Y-shaped and in rodents it has two heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds.</p>
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| + | IgD is Y-shaped. In rodents, it has two heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds. |
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| ==Function== | | ==Function== |
− | <p>
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− | *IgD is only expressed in association with [[IgM]]
| + | IgD is only expressed in association with [[IgM]]. It is important in B-cell development. |
− | *It is important in B-cell development. </p>
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− | <br>
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| <center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center> | | <center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center> |