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[[Image:LH IgE.png|thumb|150px|right|'''IgE''']]

[[Image:LH IgE.png|thumb|250px|right|'''IgE''']]

[[Image:IgE.jpg|thumb|right|150px|IgE - B. Catchpole, RVC 2008]]

[[Image:IgE.jpg|thumb|right|250px|IgE - B. Catchpole, RVC 2008]]

<p>Unlike IgM, IgG and [[IgA]], IgE does not function as a soluble antibody and is found in low levels in blood plasma. Like [[IgA]] it is produced by plasma cells and is mainly localised to mucosal surfaces.</p>

 

 

Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors required before it can bind to the target antigen, and is found in low levels in blood plasma. Like [[IgA]], it is produced by [[B cell differentiation|plasma cells]] and is mainly localised to mucosal surfaces.

 

==Structure==

==Structure==

<p>IgE is Y-shaped with heavy chain type ε, and exists as a monomer.</p>

 

''Note: Janeway <ref>{{citation|initiallast = Janeway|initialfirst = C.A|2last = Travers|2first = P|3last = Walport|3first = M|finallast = Shlomchik|finalfirst = M.J|year = 2005|title = Immunobiology: The immune system in health and disease|ed = 6th |city = New York|pub = Garland Science Publishing|range = 156-157}}</ref> states that IgE has no hinge region whereas Tizard <ref>{{citation|initiallast = Tizard|initialfirst = I.R|year = 2004|title = Veterinary Immunology: An Introduction|ed = 7th|city = Philadelphia|pub = Saunders|range = 148-149}}</ref> indicates that it does.

IgE is Y-shaped with heavy chain type ε, and exists as a monomer.  

 

''Note: Janeway <ref>{{citation|initiallast = Janeway|initialfirst = C.A|2last = Travers|2first = P|3last = Walport|3first = M|finallast = Shlomchik|finalfirst = M.J|year = 2005|title = Immunobiology: The immune system in health and disease|ed = 6th |city = New York|pub = Garland Science Publishing|range = 156-157}}</ref> states that IgE has no hinge region whereas Tizard <ref>{{citation|initiallast = Tizard|initialfirst = I.R|year = 2004|title = Veterinary Immunology: An Introduction|ed = 7th|city = Philadelphia|pub = Saunders|range = 148-149}}</ref> indicates that it does.''

 

==Production==

==Production==

<p>It is produced when Th2 cells stimulate CD40 and produce Il-4 and Il-13 which causes B cell differentiation to plasma cells and class switching to IgE production.</p>

 

It is produced when T_H2 cells stimulate CD40 and produce IL-4 and IL-13, which causes B cell differentiation to plasma cells and class switching to IgE production.

 

==Function==

==Function==

 

*IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation

IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation when bound to target. It is involved in [[Type I Hypersensitivity|type I hypersensitivity reactions]]. Cross-linking of IgE molecules by antigens, triggers [[Mast Cells|mast cell]] and [[Eosinophil|eosinophil]] degranulation and an inflammatory response. IgE has considerable involvement in producing [[Immunity to Parasites|immunity to parasitic worms]], particularly [[:Category:Nematodes|nematode]] parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic [[Eosinophils|eosinophils]], [[Macrophages|macrophages]], and so on.

*It is involved in type I hypersensitivity reactions

 

*Cross-linking of IgE molecules by antigen triggers mast cell degranulation and an inflammatory response</p>

*IgE has considerable involvement in producing immunity to parasitic worms and particularly nematode parasites

**It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on</p>

==References==

==References==

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<references />

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<center><b>^{[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E - WikiBlood|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]}</b></center>

 

[[Immunoglobulins|Immunoglobulins]]

 

[[Immunoglobulin A|Immunoglobulin A]]

 

[[Immunoglobulin D|Immunoglobulin D]]

 

[[Immunoglobulin G|Immunoglobulin G]]  

 

[[Immunoglobulin M|Immunoglobulin M]]

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