Changes

Histopathology reveals centrilobular necrosis. Haematoxylin and eosin staining reveals basophilic intranuclear inclusion bodies in hepatocytes and macrophages.

Histopathology reveals centrilobular necrosis. Haematoxylin and eosin staining reveals basophilic intranuclear inclusion bodies in hepatocytes and macrophages.

It is possible to use immunofluorescence to stain for viral antigen in vascular endothelium.

It is possible to use immunofluorescence to stain for viral antigen in vascular endothelium.

==Treatment==

==Treatment==

Treatment for infectious canine hepatitis is supportive and symptomatic. This may include fluid therapy, and blood or plasma in the event of clotting disorders. Heparin may be necessary if disseminated intravascular coagulation arises, and intravenous glucose can be used to correct hypoglycaemia. Hepatic encephalopathy can be treated with lactulose and antibiotics such as neomycin or ampicillin, and S-adenosyl methionine can be provided as a glutathione precursor or replacement to help minimise damage and aid liver regeneration. Anti-emetic drugs can also be used.

Treatment for infectious canine hepatitis is supportive and symptomatic. This may include fluid therapy, and blood or plasma in the event of clotting disorders. Heparin may be necessary if disseminated intravascular coagulation arises, and intravenous glucose can be used to correct hypoglycaemia. Hepatic encephalopathy can be treated with lactulose and antibiotics such as neomycin or ampicillin, and S-adenosyl methionine can be provided as a glutathione precursor or replacement to help minimise damage and aid liver regeneration. Anti-emetic drugs can also be used.

 

===Prevention===

===Prevention==

A vaccine is available for infectious canine hepatitis and is a "core" canine vaccine. The vaccine is a live attenuated strain of CAV2, which confers cross-protection against CAV1. The primary course consists of two vaccinations given three to four weeks apart, and boosters are required at least every two to three years.

A vaccine is available for infectious canine hepatitis and is a "core" canine vaccine. The vaccine is a live attenuated strain of CAV2, which confers cross-protection against CAV1. The primary course consists of two vaccinations given three to four weeks apart, and boosters are required at least every two to three years.=

In an outbreak, isolation, barrier nursing and strict hygiene are necessary to prevent spread of disease.

In an outbreak, isolation, barrier nursing and strict hygiene are necessary to prevent spread of disease.

==Prognosis==

==Prognosis==