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* Diffuses across the cell membrane - lipophillic (essentially steroidal)
 
* Diffuses across the cell membrane - lipophillic (essentially steroidal)
* Of the principal cells of [[Distal Tubule - Anatomy & Physiology| distal tubule]] and [[Collecting Duct - Anatomy & Physiology| Collecting Duct]]
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* Of the principal cells of [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Distal Tubule| distal tubule]] and [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Collecting Duct| collecting duct]]
 
* Binds to cytoplasmic receptors
 
* Binds to cytoplasmic receptors
 
* Works by altering gene transcription and increases synthesis of proteins
 
* Works by altering gene transcription and increases synthesis of proteins
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