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[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p><sup>© Nottingham Uni</sup>]]Macrophages are large, round cells that contain a central round nucleus and have abundant clear, often vacuolated, cytoplasm. Macrophages acts as sentinel cells, have a role in destroying bacteria, protozoa and tumour cells, and release substances that act upon other immune cells. Macrophages are phagocytic, long lived and are found throughout the body.
[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p><sup>© Nottingham Uni</sup>]]Macrophages are large, round cells that contain a central round nucleus and have abundant clear, often vacuolated, cytoplasm. Macrophages acts as sentinel cells, have a role in destroying bacteria, protozoa and tumour cells, and release substances that act upon other immune cells. Macrophages are phagocytic, long lived and are found throughout the body.
==Development==
==Development==
Macrophages are either derived from blood borne [[Monocytes - WikiBlood|monocytes]] which have migrated into tissue and differentiated, or from dividing macrophages within the tissue.
Macrophages are either derived from blood borne [[Monocytes|monocytes]] which have migrated into tissue and differentiated, or from dividing macrophages within the tissue.
===Locations===
===Locations===
<p>Macrophages are present throughout the body with large numbers in the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Bone Marrow - Anatomy & Physiology|bone marrow]] and [[Spleen - Anatomy & Physiology|spleen]]. In connective tissue macrophages are fixed and referred to as tissue histocytes. Sentinel macrophages in the lung are called alveolar macrophages, while in the [[Liver - Anatomy & Physiology|liver]] they are called Kupffer cells. In the brain they are microglia with long cytoplasmic processes.</p>
<p>Macrophages are present throughout the body with large numbers in the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Bone Marrow - Anatomy & Physiology|bone marrow]] and [[Spleen - Anatomy & Physiology|spleen]]. In connective tissue macrophages are fixed and referred to as tissue histocytes. Sentinel macrophages in the lung are called alveolar macrophages, while in the [[Liver - Anatomy & Physiology|liver]] they are called Kupffer cells. In the brain they are microglia with long cytoplasmic processes.</p>
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<center><b><sup>Blood cells: [[Erythrocytes - WikiBlood|Erythrocytes]] |
<center><b><sup>Blood cells: [[Erythrocytes - WikiBlood|Erythrocytes]] |
[[Basophils - WikiBlood|Basophils]], [[Eosinophils - WikiBlood|Eosinophils]], [[Lymphocytes|Lymphocytes]], [[Macrophages|Macrophages]], [[Mast Cells - WikiBlood|Mast cells]], [[Monocytes - WikiBlood|Monocytes]] & [[Neutrophils|Neutrophils]] | [[Thrombocytes|Thrombocytes]] & [[Thrombopoiesis - WikiBlood#Megakaryocyte|Megakaryocytes]]</sup></b></center>
[[Basophils - WikiBlood|Basophils]], [[Eosinophils - WikiBlood|Eosinophils]], [[Lymphocytes|Lymphocytes]], [[Macrophages|Macrophages]], [[Mast Cells - WikiBlood|Mast cells]], [[Monocytes|Monocytes]] & [[Neutrophils|Neutrophils]] | [[Thrombocytes|Thrombocytes]] & [[Thrombopoiesis - WikiBlood#Megakaryocyte|Megakaryocytes]]</sup></b></center>