Author, Donkey, Bureaucrats, Administrators
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Caused by a herpesvirus
Caused by a herpesvirus
==== Hosts ====
*The most important disease of '''unvaccinated backyard chicken flocks'''
*The most important disease of '''unvaccinated backyard chicken flocks'''
====Pathogenesis====
==== Pathogenesis ====
*Replicates initially in the lungs and B cells
*Enters feather follicles: produces virus-laden dander that is shed into litter
*Replicates initially in the lungs and B cells
*Reaches T cells, causing proliferation without virus protein production
*Enters feather follicles: produces virus-laden dander that is shed into litter
*T cells localize in brain or nerves causing '''encephalitis'''
*Reaches T cells, causing proliferation without virus protein production
*T cells localize in brain or nerves causing '''encephalitis'''
*End stage: massive visceral tumors
*End stage: massive visceral tumors
====Epidemiology====
==== Epidemiology ====
*More virulent strains evolving: presents a challenge to vaccinal immunity
*More virulent strains evolving: presents a challenge to vaccinal immunity
====Control====
==== Control ====
*Removal of litter between batches of chicks
*Removal of litter between batches of chicks
*'''Vaccines''' administered in ovo at 18 days
*'''Vaccines''' administered in ovo at 18 days
[[Category:Herpesviridae]][[Category:Poultry]]
[[Category:To_Do_-_Clinical/Viruses]]
[[Category:Herpesviridae]] [[Category:Avian Viruses]] [[Category:To_Do_-_Clinical/Viruses]]