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*Infection by dipterous flies in moist body areas (''eg.'' perineum)
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Also Known As '''''– Fly-strike – Wound myiasis – Maggots – Strike – Fly infestation – Wool maggots'''''
*Commonly affects sheep - [[Bacterial skin infections - Pathology#Ovine fleece rot|ovine fleece rot]]
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*Grossly:
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**Matted hair or wool, may be in wounds
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**Multiple holes or ulcers
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**Malodour
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*May result in death due to septicaemia or toxaemia
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*'''Cuterebra myiasis'''
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**Caused by ''Cuterebra'' sp
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**Young animals come into contact with eggs on stones or plants
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**Nodules with larvae in subcutis + respiration openings to surface
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*'''Hypoderma myiasis'''
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**Caused by ''Hypoderma lineatum'' or ''H. bovis''
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**Mainly affects cattle
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**Skin of legs is penetrated -> migration through [[Oesophagus - Anatomy & Physiology|oesophagus]] or vertebral canal to subcutis of back
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**Cause subcutaneous nodules with respiration openings
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**Larvae in cavity with fibrin and eosinophils surrounded by granulation tissue with eosinophil clusters
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*'''Screwworm myiasis'''
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**Occurs in Africa, Asia, Central and South America
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**Larvaae are deposited in wounds
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**Penetrate and liquify tissue
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[[File:Myiasis cat.jpg|thumb|200px|right|Cat with myiasis. Wikimedia Commons]]
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==Pathogenesis==
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[[File:Gasterophilus larvae.jpg|thumb|200px|right|Larval form of ''Gasterophilus spp'' stomach botfly. Wikimedia Commons]]
*Production losses
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**Annoyance
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**Bites can lead to secondary infection by [[Myiasis Producing Flies|myiasis producing flies]] and other muscid species
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*Disease transmission
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Caused By – '''[[Myiasis Producing Flies]]'''
**Pathogenic bacteria and viruses via mechanical transmission
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**Helminths can be introduced into the host
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***E.g. ''Stephanofiliaria'' a filarial nemadode found in the skin of cattle overseas
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==Haematobia irritans==
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==Introduction==
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Myiasis is caused by infestation of live hosts with '''[[Biting Flies | dipterous larvae]]'''.
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Small and large ruminants and poultry can be affected.
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These larvae then feed on the host’s living and dead tissue.
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[[Myiasis Producing Flies]] can be '''obligate or facultative'''.
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==Myiasis Causing Flies==
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===Obligate===
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'''Obligate flies''' occur exclusively '''in or on''' living vertebrates.
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''[[Oestrus ovis]], [[Gasterophilus spp]], [[Hypoderma spp]], [[Dermatobia hominis | Dermatobia spp]], [[Wohlfahrtia spp]], Cochliomyia, [[Chrysomya bezziana]] and Cordylobia.''
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===Facultative===
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'''Facultative''' flies are '''free-living''' and usually found in detritus or carrion.
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''Cochliomyia macellaria, Chrysomya megacephala, rufifacies'' and ''albiceps, Lucilla sericata and cuprina, Phormia spp, Protophormia spp'' and ''Caliphora spp.''
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For more information, see [Myiasis Producing Flies]]
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==Distribution==
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[[Myiasis Producing Flies]] are found in most regions of the world.
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==Signalment==
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Presence of '''wounds, wet fleece''' in sheep cases, recent '''surgery''', bacterial wool/skin contamination and '''faecal contamination''' are the main predisposing factors for myiasis.
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Density of stock will determine size and viability of the fly population.
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==Clinical Signs==
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Can be classified as '''cutaneous, nasopharyngeal, intestinal''' or '''urogenital'''.
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'''Pain, Irritation, Discomfort, Alopecia''' and '''Pruritus''' locally.
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'''Direct tissue damage, haemorrhage''', hyperpigmentation and secondary infection.
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[[Oestrus ovis | '''Nasal myiasis''']] causes irritation and [[Epistaxis | epistaxis]].
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'''Aural myiasis''' can cause deafness, discharge and foul exudates.
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[[Gasterophilus spp | '''Gastrointestinal myiasis''']] often causes '''ulceration, GI bleeding''', weight loss, [[Diarrohea | diarrhoea]] and pupae are voided in faeces.
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[[Hypoderma spp | '''Warble flies''']] cause '''cysts''' along the midline of the '''back'''.
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''Lucilia sericata'' tends to cause leions on the inner '''thighs and perineum''' due to faecal soiling.
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''[[Wohlfahrtia spp]]'' cause '''genital lesions''' on the vulva and prepuce.
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'''Loss of feathers''' and soiling of the vent is seen in '''poultry'''.
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In severe cases, anaemia, anaphylaxis and toxaemia may be fatal.
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Reduced feeding and consequent weight loss and infertility.
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==Diagnosis==
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Diagnosis is primarily dependent on '''observation of larvae''' on the host or in the faeces.
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Larvae may also be observed in the carcass at '''post-mortem'''.
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Gastroscopy may be used in the case of [[Gasterophilus spp | gastric myiasis]].
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'''[[ELISA testing | ELISA]]''' is also available for ''[[Hypoderma spp]]'' and ''[[Oestrus ovis]]''.
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'''PCR''' is available for ''Cochliomyia spp''.
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==Treatment==
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Treatment with '''[[Ectoparisiticides | ectoparasiticides]]''' is usually effective.
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Administration can be '''oral, topical or by subcutaneous injection''' and the type of myiasis should be considered when deciding upon route of administration.
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'''Ivermectin''' and '''doramectin''' are both effective in the control of [[Oestrus ovis | nasal myiasis]] ,[[Hypoderma spp | warble fly]] and [[Dermatobia hominis | Dermatobia]] when '''injected'''.
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'''Moxidectin''' is the main drug for '''oral treatment'''. It is effective against [[Gasterophilus spp]].
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'''Topical treatment''' by '''pour-on or dipping''' is most effective against '''cutaneous/subcutaneous myiasis'''. A huge range of products are available. Resistance should be considered and monitored.
 
==Control==
 
==Control==
*Resident fly so easier to control than visiting flies as spends more time in contact with the host
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Preventative treatment with '''[[Ectoparasiticides | ectoparasiticides]]''' is common.
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Release of '''sterile insects''' is also possible and effective but expensive.
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*However, [[Ectoparasiticides|insecticide]] resistance can occur quicker
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'''Vaccines''' are available against ''[[Hypoderma spp]]'' and ''Lucilia spp.''
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==References==
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<references/>
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Animal Health & ProductIon Compendium, '''Myiasis datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
       
[[Category:Integumentary System - Parasitic Infections]]
 
[[Category:Integumentary System - Parasitic Infections]]
[[Category:To_Do_-_Steph]]
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[[Category:To_Do_-_CABI review]]
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