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Pancreatic Atrophy, Exocrine (view source)
Revision as of 17:48, 24 February 2011
, 17:48, 24 February 2011no edit summary
AKA Pancreatic Acinar Athropy (PAA)
[[Image:Pancreatic atrophy.jpg|right|thumb|100px|<small><center>Pancreatic atrophy (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
[[Image:Pancreatic atrophy.jpg|right|thumb|100px|<small><center>Pancreatic atrophy (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
<big>Extra information for Exocrine Pancreatic Atrophy
Exocrine pancreatic atrophy in GSDs and rough coated collies: an end result of lymphocytic pancreatitis. Wiberg ME et al. Vet Path (1999) 36 530-41</big>
*Histological changes in EPI dogs
*Histological changes in the subclinical pancreas (ie; just TLI):
*Patchy areas of normal and abnormal exocrine parenchyma
*Consistently a marked lymphoid infiltrate (lesser numbers of plasma cells seen, occasional eosinophils), starting in the border zone with gradual loss of the pancreatic parenchyma
*Mainly CD3+ T cells, with fewer CD3+ lymphocytes.
*Some lymphoid follicles (mainly B cells) scattered throughout.
*No associated increase in fibrous connective tissue
*Some intra-acinar lymphocytes seen
*As tissue destruction continued, ductal structures became more obvious
*Apoptosis seen in the acini often in normal looking acini.
*Ultrastructure
**Degenerative changes in acinar cells – dilation of rER, swelling of mitochondria, nuclear pyknosis, aptotitic bodies
*Histology of clinical EPI:
**Totally atrophied exocrine pancreas
**Some dogs had areas of normal acinar structures
**Little inflammation in the border zone
**Most of the remaining exocrine pancreas was disorganized, prominent ducts, increased amounts of adipose tissue.
**Slight increase in fibrous tissue compared to subclinical phase, but replacement with fat was more prominent than fibrosis.
**No ductular epithelial hyperplasia evident
*Ultrastructure
**Often no remaining acinar cells
*Suggests and immune-mediated destruction - ?hereditary
*Islet cells usually well preserved in the atrophied pancreas.
[[Category:Pancreas - Degenerative Pathology ]]
[[Category:Pancreatic Diseases - Dog]]
[[Category:To_Do_-_Clinical]]