Changes

===Inhibin===

===Inhibin===

Inhibin is a type of glycoprotein that is synthesised within the granulosa cells in females and in sertoli cells in the male. In both males and females the target organ for inhibin is the anterior pituitary, specifically the gonadotroph cells. In the male inhibin inhibits FSH secretion whilst in females it stimulates FSH secretion.

Inhibin is a type of glycoprotein that is synthesised within the granulosa cells in females and in sertoli cells in the male. In both males and females the target organ for inhibin is the anterior pituitary, specifically the gonadotroph cells. In the male inhibin inhibits FSH secretion, which together with decreased concentrations of LH and testosterone results in decreased spermatogenesis and therefore decreased sperm output and quality.

In females inhibin stimulates FSH secretion. When inhibin is secreted a relatively higher concentration of LH is secreted from the anterior pituitary gland than FSH. Therefore during follicle development, the increased LH concentration causes cessation of the recruitment of further follicles under the effect of FSH. The hormonal changes resulting from the production of inhibin cause some of the previously recruited follicles to undergo atresia.

 

===Activin===

===Activin===

Activin is a glycoprotein that is produced within granulosa cells in females and sertoli cells in the male. The target tissue for activiin in the male is the epididymis whilst in the female it is the anterior pituitary gland, specifically gonadotroph cells. In males and females activin stimulates FSH secretion.

Activin is a glycoprotein that is produced within granulosa cells in females and sertoli cells in the male. The target tissue for activiin in the male is the epididymis whilst in the female it is the anterior pituitary gland, specifically gonadotroph cells. In males and females activin stimulates FSH secretion.