Testosterone is a steroid hormone that is produced in the leydig cells within the testes and also via theca interna cells within follicles. In males the target tissue for testosterone are the anterior pituitary gland, specifically the gonadotroph cells. In females the target tissues are the brain, skeletal muscle and granulosa cells. This is because testosterone acts as a substrate for estradiol. The synthesis of testosterone rather than estradiol can lead to abnormal masculinisation in females. In males the primary action of testosterone is anabolic growth, spermatogenesis promotion and promotion of secretion from the accessory sex glands. | Testosterone is a steroid hormone that is produced in the leydig cells within the testes and also via theca interna cells within follicles. In males the target tissue for testosterone are the anterior pituitary gland, specifically the gonadotroph cells. In females the target tissues are the brain, skeletal muscle and granulosa cells. This is because testosterone acts as a substrate for estradiol. The synthesis of testosterone rather than estradiol can lead to abnormal masculinisation in females. In males the primary action of testosterone is anabolic growth, spermatogenesis promotion and promotion of secretion from the accessory sex glands. |