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Under normal physiological conditions, diastole can be divided into four phases:
 
Under normal physiological conditions, diastole can be divided into four phases:
1. Isovolumetric relaxation
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:1. Isovolumetric relaxation
2. Rapid ventricular filling
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:2. Rapid ventricular filling
3. Slow ventricular filling (diastasis)
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:3. Slow ventricular filling (diastasis)
4. Atrial contraction
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:4. Atrial contraction
    
Ventricular filling is influenced by ventricular relaxation, ventricular compliance, atrial contraction and the pressure gradient between the left and right ventricles. The intraventricular pressure gradient is important as it causes an 'untwisting' at the cardiac apex in early diastole; which has a suction effect contributing to ventricular filling.
 
Ventricular filling is influenced by ventricular relaxation, ventricular compliance, atrial contraction and the pressure gradient between the left and right ventricles. The intraventricular pressure gradient is important as it causes an 'untwisting' at the cardiac apex in early diastole; which has a suction effect contributing to ventricular filling.
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