*Increased competitiveness and shifts in status relationships: both with people and [more probably] other dogs in the household. Especially important where status related problems already exist.
+
*Increased owner directed aggression and inter-dog competitive aggression (in cases where these problems already exist).
'''Caution should be taken in if the animal suffers from any of the following pre-existing medical conditions:'''
'''Caution should be taken in if the animal suffers from any of the following pre-existing medical conditions:'''
*Hyperadrenocorticism (not of pituitary origin)
*Hyperadrenocorticism (not of pituitary origin)
+
*Owner-directed aggression
'''Care should be taken if used in conjunction with any of the following drugs, which may interact and cause adverse effects:'''
'''Care should be taken if used in conjunction with any of the following drugs, which may interact and cause adverse effects:'''