Changes

A stress leuocogram is a finding on a haematological test.  It is characterised by a [[Neutrophilia|neutrophilia]], [[Monocytosis|monocytosis]], [[Lymphopaenia|lymphopaenia]] and [[Eosinopaenia|eosinopaenia]]

A stress leuocogram is a finding on a haematological test.  It is characterised by a [[Neutrophilia|neutrophilia]], [[Monocytosis|monocytosis]], [[Lymphopaenia|lymphopaenia]] and [[Eosinopaenia|eosinopaenia]]

==What can this indicate==

==What can this indicate==

A stress leucogram can be completely normal as part of the stress response.  It is caused by endogenous release of adrenaline/epinephrine which causes the release of cortisol from the [[Adrenal_Glands_-_Anatomy_&_Physiology|adrenal cortex]] - this causes the haematological parameters to change.  Adrenaline and then cortisol release can be triggered by pain, stress or excitement.   

A stress leucogram can be completely normal as part of the stress response.  It is caused by endogenous release of Adrenocorticotrophic hormone (ACTH) which causes the release of cortisol from the [[Adrenal_Glands_-_Anatomy_&_Physiology|adrenal cortex]] - this causes the haematological parameters to change.  ACTH and then cortisol release can be triggered by pain, stress or excitement.   

A stress leucogram can also be seen in [[Cushing's Disease]] (AKA hyperadrenocorticism) where there is a pathological increase in the amount of cortisol released endogenously, or via iatrogenic injection of exogenous corticosteroids.

A stress leucogram can also be seen in [[Cushing's Disease]] (AKA hyperadrenocorticism) where there is a pathological increase in the amount of cortisol released endogenously, or via iatrogenic injection of exogenous corticosteroids.

==How does it occur?==

==How does it occur?==

The glucocorticoid (whether endogenous or exogenous) causes a variety of affects on blood cells, including margination

The glucocorticoid (whether endogenous or exogenous) causes a variety of affects on blood cells, including margination