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| * They are active against gram-negative rods, including enterobacteriaceae. | | * They are active against gram-negative rods, including enterobacteriaceae. |
| * They are active against the anaerobes, ''Actinomyces'' and ''Fusobacterium'', but inactive against clostridial species and anaerobic cocci. | | * They are active against the anaerobes, ''Actinomyces'' and ''Fusobacterium'', but inactive against clostridial species and anaerobic cocci. |
− | * Reistance is now widespread. | + | * Resistance is now widespread. |
| * Drugs which contain a PABA nuclear core, such as procaine, antagonise their actions. | | * Drugs which contain a PABA nuclear core, such as procaine, antagonise their actions. |
− |
| |
| | | |
| ==Pharmacokinetic Considerations== | | ==Pharmacokinetic Considerations== |
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| *some of these casue hepatic necrosis in susceptible animals | | *some of these casue hepatic necrosis in susceptible animals |
| *has been associated with a reduced capability of detoxifying the metabolites | | *has been associated with a reduced capability of detoxifying the metabolites |
− | *Doberman Pincher breed appear to be susceptible | + | *Doberman Pinscher breed appears to be susceptible |
| [[Category:Hepatotoxicity,_Drug_induced]] | | [[Category:Hepatotoxicity,_Drug_induced]] |
| [[Category:To_Do_-_Clinical]] | | [[Category:To_Do_-_Clinical]] |