Testicular Feminisation

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Aetiology

• Genotype XY as should be in the male.
• Testes develop normally and secrete Androgens and MIH
• Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.

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Consequence

• Wolffian Ducts regress, allowing formation of female external genetalia:
  • Labia
  • Clitoris
  • Vagina
• Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
• Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.