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[[Image:thrombosis dog nose 2.jpg|right|thumb|125px|<small><center>'''Nasal thrombosis (dog)'''. Courtesy of T. Scase</center></small>]]
[[Image:thrombosis dog nose 2.jpg|right|thumb|125px|<small><center>'''Nasal thrombosis (dog)'''. Courtesy of T. Scase</center></small>]]
===Description===
===Description===
Thrombosis is a localized or generalized intravascular clot formation. Thrombi form as the result of trauma or pathological processes affecting the blood vessel endothelium or disturbances to blood flow and/or blood composition. Some diseases such as infective endocarditis and heart worm increase the risk of thrombi formation.
Thrombosis is a localized or generalized intravascular clot formation. Thrombi form as the result of trauma or pathological processes affecting the blood vessel endothelium or disturbances to blood flow and/or blood composition. Some diseases such as infective endocarditis and heart worm increase the risk of thrombi formation.
===Thrombosis formation===
===Thrombosis formation===
[[Image:DIC thrombus.jpg|right|thumb|200px|<small><center>'''DIC thrombus'''. Courtesy of A. Jefferies</center></small>]]
The process usually begins with platelets becoming sticky. They adhere to each other and to the endothelium. This increased "stickiness" is induced by contact with:
The process usually begins with platelets becoming sticky. They adhere to each other and to the endothelium. This increased "stickiness" is induced by contact with:
* Collagen
* Collagen