Changes

In dogs confirmed with TBE infection, '''lymphohistiocytic meningitis''' is seen with '''neuronal necrosis, glial karyorrhexis and microglial proliferation'''. Perivascular cuffs can be present in all regions of the brain.

In dogs confirmed with TBE infection, '''lymphohistiocytic meningitis''' is seen with '''neuronal necrosis, glial karyorrhexis and microglial proliferation'''. Perivascular cuffs can be present in all regions of the brain.

Viral antigen is most consistently found in the neuroparenchyma surrounding the '''fourth ventricle''' but also in the cerebellum, mesencephalon, thalamus, hippocampus and neocortex.<ref name="Wessenbock">Weissenböck, H (1999) '''Post-mortem diagnosis of tick-borne encephalitis in dogs'''. ''Tierärztliche Umschau'', 54(5):249-255; 15</ref> CSF can also be used. Virus can be detected by immunohistology.<ref name="Weissenbock" /> '''Antibodies can be detected in serum and CSF by [[ELISA testing|ELISA]].'''

Viral antigen is most consistently found in the neuroparenchyma surrounding the '''fourth ventricle''' but also in the cerebellum, mesencephalon, thalamus, hippocampus and neocortex.<ref name="Weissenbock">Weissenböck, H (1999) '''Post-mortem diagnosis of tick-borne encephalitis in dogs'''. ''Tierärztliche Umschau'', 54(5):249-255; 15</ref> CSF can also be used. Virus can be detected by immunohistology.<ref name="Weissenbock"/> '''Antibodies can be detected in serum and CSF by [[ELISA testing|ELISA]].'''

==Treatment==

==Treatment==