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===Arteriogenesis===
 
===Arteriogenesis===
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The volume and pressure of blood flowing in the network dictates the degree of development of individual vessels. The channels which carry blood at high pressure develop additional tissue layers from the surrounding mesoderm thereby becoming thick-walled. The diameter of these vessels also increases and they become known as arteries. Differentiation of mesenchymal cells to smooth muscle is driven by growth factors released from endothelial cells.
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