The niacin derivatives, NAD and NADP, are required cofactors in dehydrogenase/reductase reactions. In general, NAD is used in catabolic reactions involving glucose, fatty acid, ketone, and amino acid metabolism while NADP is used in synthesis of [[Fat Overview - Nutrition|lipids and cholesterol]].<ref name="McCormick" /> Both NAD and NADP also act as electron donors to the riboflavin-derivative flavin adenine dinucleotide (FAD) in the mitochondrial electron transport chain during adenosine triphosphate (ATP) production. | The niacin derivatives, NAD and NADP, are required cofactors in dehydrogenase/reductase reactions. In general, NAD is used in catabolic reactions involving glucose, fatty acid, ketone, and amino acid metabolism while NADP is used in synthesis of [[Fat Overview - Nutrition|lipids and cholesterol]].<ref name="McCormick" /> Both NAD and NADP also act as electron donors to the riboflavin-derivative flavin adenine dinucleotide (FAD) in the mitochondrial electron transport chain during adenosine triphosphate (ATP) production. |