Changes

==Roles in the Body==

==Roles in the Body==

#'''Energy Metabolism''': Pantothenic acid as CoA forms acetyl-CoA, which condenses with oxaloacetate to form citrate in the tricarboxylic acid (TCA) cycle during oxidation of glucose and fatty acids<ref name="Silber"/><ref name="NRC">National Research Council (NRC). Vitamins. In Nutrient Requirements for Dogs and Cats. 2006 Washington, DC: National Academies Press p.223-225.</ref>

#'''Energy Metabolism''': Pantothenic acid as CoA forms acetyl-CoA, which condenses with oxaloacetate to form citrate in the tricarboxylic acid (TCA) cycle during oxidation of glucose and fatty acids<ref name="NRC">National Research Council (NRC). Vitamins. In Nutrient Requirements for Dogs and Cats. 2006 Washington, DC: National Academies Press p.223-225.</ref><ref name="Sweetman">Sweetman L. Pantothenic acid and biotin. In Biochemical and physiological aspects of human nutrition. 2000 Philadelphia, PA: WB Saunders Company p. 520-529.</ref>

#'''Synthesis Reactions''': Acetyl-CoA is used to form succinyl-CoA for synthesis of the porphyrin ring in [[Erythrocytes#Function|haemoglobin]]; CoA involved in the synthesis of acetylcholine, ketone bodies, fatty acids, cholesterol, and [[Vitamin D (Cholecalciferol) - Nutrition|vitamin D]]<ref name="Silber"/><ref name="NRC"/>.

#'''Synthesis Reactions''': Acetyl-CoA is used to form succinyl-CoA for synthesis of the porphyrin ring in [[Erythrocytes#Function|haemoglobin]]; CoA involved in the synthesis of acetylcholine, ketone bodies, fatty acids, cholesterol, and [[Vitamin D (Cholecalciferol) - Nutrition|vitamin D]]<ref name="NRC"/><ref name="Sweetman"/>.

==Consequences of Pantothenic Acid Deficiency==

==Consequences of Pantothenic Acid Deficiency==

====Dogs:====  

====Dogs:====  

Dogs and puppies fed pantothenic acid-deficient diets experienced poor food intake and can develop sudden prostration and coma, tachypnea and tachycardia, gastritis, enteritis, and [[Intussusception|intussuseptions]]; death can results if efficiency not corrected<ref name="Plesofsky"/><ref name="Sweetman">Sweetman L. Pantothenic acid and biotin. In Biochemical and physiological aspects of human nutrition. 2000 Philadelphia, PA: WB Saunders Company p. 520-529.</ref>.

Dogs and puppies fed pantothenic acid-deficient diets experienced poor food intake and can develop sudden prostration and coma, tachypnea and tachycardia, gastritis, enteritis, and [[Intussusception|intussusceptions]]; death can results if efficiency not corrected<ref name="Silber"/><ref>Schaefer AE, et al. Pantothenic acid deficiency studies in the dog. J Biol Chem 1942;143:321-330.</ref>.

 

====Cats:====  

====Cats:====  

There are no published reports of pantothenic acid deficiencies in adults, but kittens fed pantothenic acid deficient diets experience poor growth rates<ref>Schaefer AE, et al. Pantothenic acid deficiency studies in the dog. J Biol Chem 1942;143:321-330.</ref>.

There are no published reports of pantothenic acid deficiencies in adults, but kittens fed pantothenic acid deficient diets experience poor growth rates.<ref>Gershoff SN and Gottlieb LS. Pantothenic acid deficiency in cats. J Nutr 1964;82:135-138.</ref>

 

 

Conditions associated with diuresis (e.g. chronic disease, such as [[:Category:Kidney - Pathology|renal disease]] or [[Diabetes Insipidus|diabetes]], or therapeutic intervention, such as [[Fluid therapy|intravenous fluids]] or increased water intake with management of [[Cystitis|lower urinary diseases]]) can result in increased loss of pantothenic acid and may increase daily requirements. Patient on chronic haemodialysis are at an increased risk for developing a deficiency.

Conditions associated with diuresis (e.g. chronic disease, such as [[:Category:Kidney - Pathology|renal disease]] or [[Diabetes Insipidus|diabetes]], or therapeutic intervention, such as [[Fluid therapy|intravenous fluids]] or increased water intake with management of [[Cystitis|lower urinary diseases]]) can result in increased loss of pantothenic acid and may increase daily requirements. Patient on chronic haemodialysis are at an increased risk for developing a deficiency.

==References==

==References==

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[[Category:Vitamins]]

[[Category:Vitamins]]