Line 1: |
Line 1: |
− | * '''Vitamin K'''
| + | ==Introduction== |
− | ** Absolute or relative deficiency of vitamin K can give rise to abnormal prothrombin levels or activity.
| + | The absolute or relative deficiency of vitamin K can give rise to defective coagulation. |
− | *** Gives defective coagulation.
| + | [[Anticoagulant Rodenticide Toxicity|Anticoagulant rodenticide toxiticy]] is one of the most common causes of acquired coagulopathy in small animals. Warfarin itself has a short half-life and a fairly low toxicity in non-rodent species, so unless large or repeated doses are consumed clinical bleeding is rare. However, the second generation anticoagulant rodenticides are far more potent, and it is possible for a domestic animal to acquire secondary poisoning by ingesting a poisoned rodent<sup>1</sup>. Dogs are most commonly effected, but predator species such as cats and owls do occasionally suffer from secondary poisonings. |
| | | |
− | Also see [[Warfarin Poisoning]]
| + | The [[Normal_Mechanisms_of_Haemostatic_Control#Coagulation_physiology|clotting factors]] - factor VII, factor XI and factors II and X in the extrinsic, intrinsic and common pathways respectively are dependent on Vitamin K when activated by the coagulation cascade. |
| | | |
− | [[Category:Coagulation Defects]] | + | ==Other Causes of Vitamin K deficiencies== |
| + | Malabsorption syndromes and sterilisation of the gastrointestinal tract by prolonged antibiotic usage will also result in the depletion of vitamin K-dependent clotting factors<sup>2</sup>. In herbivores, fungi growing on poorly prepared hay or silage containing sweet vernal grass or sweet clover may break down natural coumarins in the plants to form dicoumarol and cause poisoning. |
| + | |
| + | ==Replacement of Vitamin K== |
| + | [[Anticoagulant_Rodenticide_Toxicity#Treatment|Vitamin K<sub>1</sub>]] is available as a subcutaneous treatment for cases of [[Anticoagulant Rodenticide Toxicity|rodenticide poisoning]]. Alternatively, whole blood or plasma transfusion provides vitamin K dependent clotting factors, which can control symptoms in severe acute cases. |
| + | |
| + | ==References== |
| + | #Campbell, A (1999) Common causes of poisoning in small animals. ''In Practice'', '''21(5)''', 244-249. |
| + | #Tilley, L P and Smith, W K (2007) '''Blackwell's Five Minute Veterinary Consult: Canine and Feline (Fourth Edition)''', ''Blackwell''. |
| + | |
| + | |
| + | [[Category:Coagulation Defects]][[Category:Lymphoreticular and Haematopoietic Diseases - Dog]] |
| + | [[Category:Cardiology Section]] |