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==Effects of High Zinc Intakes==
==Effects of High Zinc Intakes==
===Dog:===
===Dog:===
'''Zinc is of relatively low toxicity in dogs'''. In fact some studies have shown beneficial effects of zinc at concentrations higher than the accepted nutritional requirement. Marsh et al.<ref>Marsh, KA, Ruedisueli, FL, Coe, SL, Watson, TDG (2000). “Effects of zinc and linoleic acid supplementation on the skin and coat quality of dogs receiving a complete and balanced diet”. Vet. Dermatol. 11:277-284.</ref> reported that feeding a complete and balanced diet containing higher than normal levels of zinc (400 mg/kg DM) and linoleic acid (6% DM) to black Labrador retrievers for 9 weeks was associated with significant improvements in coat condition. Dogs fed the high zinc level on its own showed a significant decrease in transepidermal water loss.
'''Zinc is of relatively low toxicity in dogs'''. In fact some studies have shown beneficial effects of zinc at concentrations higher than the accepted nutritional requirement. Marsh ''et al.''<ref>Marsh, KA, Ruedisueli, FL, Coe, SL, Watson, TDG (2000). “Effects of zinc and linoleic acid supplementation on the skin and coat quality of dogs receiving a complete and balanced diet”. Vet. Dermatol. 11:277-284.</ref> reported that feeding a complete and balanced diet containing higher than normal levels of zinc (400 mg/kg DM) and linoleic acid (6% DM) to black Labrador retrievers for 9 weeks was associated with significant improvements in coat condition. Dogs fed the high zinc level on its own showed a significant decrease in transepidermal water loss.
Therapeutic doses of zinc of about 20 mg/kg bodyweight/day (equivalent to a dietary zinc concentration of approximately 1100 mg/kg DM for a Bedlington terrier weighing 9 kg), have been given to certain dog breeds such as the Bedlington terrier, Labrador retriever, West Highland white terrier and Dobermann pinscher, which have an inherited defect that results in toxic excesses of [[Copper - Nutrition|copper]] in the [[Liver - Anatomy & Physiology|liver]], causing [[Hepatitis, Chronic|hepatitis]] and [[cirrhosis]]. Zinc supplementation is continued for 2 to 3 months, followed by halving the dose thereafter to block copper absorption and decrease copper accumulation in the liver<ref>Brewer, G, Dick, R, Schall, W, Yuzbasiyan-Gurkan, V, Mullaney, T, Pace, C, Lindgren, J, Thomas, M, Padgett, G (1992). “Use of zinc acetate to treat copper toxicosis in dogs”. J. Am. Vet. Med. Assoc. 210:564-568.</ref><ref>Hoffmann, G, Jones, PG, Biourge, V, van den Ingh, TSGAM, Mesu, SJ, Bode, P, Rothuizen, J (2009). “Dietary management of hepatic copper accumulation in Labrador retrievers”. J. Vet. Int. Med. 23:957-963.</ref> [WikiVet Link to Copper].
Therapeutic doses of zinc of about 20 mg/kg bodyweight/day (equivalent to a dietary zinc concentration of approximately 1100 mg/kg DM for a Bedlington terrier weighing 9 kg), have been given to certain dog breeds such as the Bedlington terrier, Labrador retriever, West Highland white terrier and Dobermann pinscher, which have an inherited defect that results in toxic excesses of [[Copper - Nutrition|copper]] in the [[Liver - Anatomy & Physiology|liver]], causing [[Hepatitis, Chronic|hepatitis]] and [[cirrhosis]]. Zinc supplementation is continued for 2 to 3 months, followed by halving the dose thereafter to block copper absorption and decrease copper accumulation in the liver<ref>Brewer, G, Dick, R, Schall, W, Yuzbasiyan-Gurkan, V, Mullaney, T, Pace, C, Lindgren, J, Thomas, M, Padgett, G (1992). “Use of zinc acetate to treat copper toxicosis in dogs”. J. Am. Vet. Med. Assoc. 210:564-568.</ref><ref>Hoffmann, G, Jones, PG, Biourge, V, van den Ingh, TSGAM, Mesu, SJ, Bode, P, Rothuizen, J (2009). “Dietary management of hepatic copper accumulation in Labrador retrievers”. J. Vet. Int. Med. 23:957-963.</ref> [WikiVet Link to Copper].
===Cat:===
===Cat:===
Sterman et al.<ref>Sterman, M, Shouse, M, Fairchild, M, Belsito, O (1986). “Kindled seizure induction alters and is altered by zinc absorption”. Brain Res. 383:382-386.</ref> fed adult cats a dietary zinc content of 600 mg/kg DM for 6 weeks with no apparent adverse effects, although the blood zinc concentration increased compared with control cats fed a zinc level of 100 mg/kg DM. '''This suggests that, like the dog, cats can tolerate zinc concentrations well above the nutritional requirement'''.
Sterman et al.<ref>Sterman, M, Shouse, M, Fairchild, M, Belsito, O (1986). “Kindled seizure induction alters and is altered by zinc absorption”. Brain Res. 383:382-386.</ref> fed adult cats a dietary zinc content of 600 mg/kg DM for 6 weeks with no apparent adverse effects, although the blood zinc concentration increased compared with control cats fed a zinc level of 100 mg/kg DM. '''This suggests that, like the dog, cats can tolerate zinc concentrations well above the nutritional requirement'''.