Changes

<p>Grossly the lymph nodes are round or bean shaped and have an outer cortex and an inner medulla. Microscopically the nodes have follicles, paracortical zones and medullary cords and sinuses. At the hilum the medulla is present on the outer part of the node. Lymph nodes are located in series with [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessels]]. Afferent vessels enter the node on its convex side and efferent vessels exit on its concave side.</p>

<p>Grossly the lymph nodes are round or bean shaped and have an outer cortex and an inner medulla. Microscopically the nodes have follicles, paracortical zones and medullary cords and sinuses. At the hilum the medulla is present on the outer part of the node. Lymph nodes are located in series with [[Lymphatic Vessels - Anatomy & Physiology|lymphatic vessels]]. Afferent vessels enter the node on its convex side and efferent vessels exit on its concave side.</p>

===Capsule and reticular framework===

===Capsule and reticular framework===

<p> The nodes are surrounded in a fibrous capsule that extends into the node as trabeculae, which provide an overall framework. Below the capsule is the sub-capsular sinus. The nodes parenchyma contain a fine network of reticular fibres and reticular cells. Reticular cells provide "scaffolding" for other cells as well as expressing surface complexes and substance to attract [[Lymphocytes - WikiBlood#T cells|T cells]], [[Lymphocytes - WikiBlood#B cells|B cells]] and [[T cell differentiation - WikiBlood#Dendritic Cells|dendritic cells]].  

<p> The nodes are surrounded by a fibrous capsule that extends into the node as trabeculae, which provide an overall framework. Below the capsule is the sub-capsular sinus. The nodes parenchyma contain a fine network of reticular fibres and reticular cells. Reticular cells provide "scaffolding" for other cells as well as expressing surface complexes and substance to attract [[Lymphocytes - WikiBlood#T cells|T cells]], [[Lymphocytes - WikiBlood#B cells|B cells]] and [[T cell differentiation - WikiBlood#Dendritic Cells|dendritic cells]].  

The cortex has aggregations of [[Lymphocytes - WikiBlood#B cells|B cells]] (in the follicles) in its outer region and a paracortex consisting of a rim of [[Lymphocytes - WikiBlood#T cells|T cells]] surrounding these follicles. [[T cell differentiation - WikiBlood#Dendritic Cells|Dendritic cells]] are also found in close association with the [[Lymphocytes - WikiBlood#T cells|T cells]].  The medulla contains medullary cords of cells ([[Lymphocytes - WikiBlood#B cells|B cells]], plasma cells and some [[Macrophages - WikiBlood|macrophages]]) and between these cords is the medullary sinus lined with endothelial cells and [[Macrophages - WikiBlood|macrophages]].</p>

The cortex has aggregations of [[Lymphocytes - WikiBlood#B cells|B cells]] (in the follicles) in its outer region and a paracortex consisting of a rim of [[Lymphocytes - WikiBlood#T cells|T cells]] surrounding these follicles. [[T cell differentiation - WikiBlood#Dendritic Cells|Dendritic cells]] are also found in close association with the [[Lymphocytes - WikiBlood#T cells|T cells]].  The medulla contains medullary cords of cells ([[Lymphocytes - WikiBlood#B cells|B cells]], plasma cells and some [[Macrophages - WikiBlood|macrophages]]) and between these cords is the medullary sinus lined with endothelial cells and [[Macrophages - WikiBlood|macrophages]].</p>