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Text replace - "Type IV Hypersensitivity - WikiBlood" to "Type IV Hypersensitivity"
'''Pathogenesis:'''
'''Pathogenesis:'''
* [[Type IV Hypersensitivity - WikiBlood|Type IV hypersensitivity]]: CD4 Th-1 cell mediated.
* [[Type IV Hypersensitivity|Type IV hypersensitivity]]: CD4 Th-1 cell mediated.
* Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction.
* Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction.
[[Category:Cell Mediated Autoimmune Diseases]][[Category:To Do - James]]
[[Category:Cell Mediated Autoimmune Diseases]][[Category:To Do - James]]