Frohlich's Adiposogenital Syndrome

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Clinical signs due to a hypothalamic dysfunction.

Decreased synthesis and release of GnRH means that the pituitary is not stimulated to release FSH or LH at normal levels. Clinically seen as:

  • Small, atrophic genitals.
  • Feminisation in the male due to lower testosterone release.

Hypothalamus damage also allows increased appetite and the animal may be obese, with excess deposition of subcutaneous fat.

Compression of local structures also leads to:

  • Mental retardation.
  • Diabetes insipidus.
  • Visual impairment.