Changes

Finally there is the other membrane-associated inhibitor - CD59. This binds the first molecule of C9 when it inserts into a cell membrane. This prevents the polymerisation of C9 obviating pore formation and cell lysis. It acts as a protective mechanism for the host cells.

Finally there is the other membrane-associated inhibitor - CD59. This binds the first molecule of C9 when it inserts into a cell membrane. This prevents the polymerisation of C9 obviating pore formation and cell lysis. It acts as a protective mechanism for the host cells.

==COMPLEMENT ASSOCIATED DISEASES==

==Complement Associated Diseases==

Most diseases associated with complement are linked to deficiencies of certain components. Deficiencies of components like C1, C2, C4, CR1 and DAF lead to autoimmune disease resulting from the inefficient removal immune complexes. This causes these complexes to lodge in many of the small capillary beds and induce inflammation. Most commonly this brings about such diseases as glomerulonephritis, vasculitis, rheumatoid arthritis and inflammation/irritation of the skin, for instance Systemic Lupus Erythematosis.

Most diseases associated with complement are linked to deficiencies of certain components. Deficiencies of components like C1, C2, C4, CR1 and DAF lead to autoimmune disease resulting from the inefficient removal immune complexes. This causes these complexes to lodge in many of the small capillary beds and induce inflammation. Most commonly this brings about such diseases as glomerulonephritis, vasculitis, rheumatoid arthritis and inflammation/irritation of the skin, for instance Systemic Lupus Erythematosis.