Changes

   Oxytocin: delivery of the [[Placenta - Anatomy & Physiology|Placenta]]

   Oxytocin: delivery of the [[Placenta - Anatomy & Physiology|Placenta]]

* Oxytocin and Prostaglandin F2α both signal by the Gαq -> IP3 + DAG pathway to raise intracellular calcium , so are able to effect each other in the [[Parturition_-_Endocrine_Control_of_Parturition_- Anatomy & Physiology#Furgesson_Reflex|Fergusson reflex]].

* Oxytocin and Prostaglandin F2α both signal by the Gαq -> IP3 + DAG pathway to raise intracellular calcium , so are able to effect each other in the [[Parturition Endocrine Control - Anatomy & Physiology#Furgesson_Reflex|Fergusson reflex]].

* COX II increases during labour, so prostaglandins will form as long as arachidonic acid is available.

* COX II increases during labour, so prostaglandins will form as long as arachidonic acid is available.

===== Corticosteroids =====

===== Corticosteroids =====

* Mimic foetal cortisol to remove the progesterone block by upregulating enzymes that will increase the oestrogen:progesterone ratio (for more information see [[Parturition_-_Endocrine_Control_of_Parturition_- Anatomy & Physiology|endocrinology of parturition]]).

* Mimic foetal cortisol to remove the progesterone block by upregulating enzymes that will increase the oestrogen:progesterone ratio (for more information see [[Parturition Endocrine Control - Anatomy & Physiology|endocrinology of parturition]]).

* '''Short Acting''': apply 2-3 days before the due date (270+ days gestation).  Complications include [[Retained_Placenta|retained placenta]] and stillbirth.

* '''Short Acting''': apply 2-3 days before the due date (270+ days gestation).  Complications include [[Retained_Placenta|retained placenta]] and stillbirth.

* '''Medium-Long Acting''': apply 2-3 weeks before the due date.  Administration after 260 days will cause no advance of the calving date. Administration before 260 days will cause neonatal mortality.  Thus use of these corticosteroids is reliant upon accurate record keeping by the farmer so that exact dates are known.

* '''Medium-Long Acting''': apply 2-3 weeks before the due date.  Administration after 260 days will cause no advance of the calving date. Administration before 260 days will cause neonatal mortality.  Thus use of these corticosteroids is reliant upon accurate record keeping by the farmer so that exact dates are known.