Changes

Loop diuretics as the name suggests work on the loop of henle.  Specifically on the [[Reabsorption and Secretion Along the Loop of Henle - Anatomy & Physiology#Thick ascending limb|thick ascending limb]] where they inhibit the activity of the sodium/potassium/2-chloride symporter.  As a result the hypertonicity of the medulla decreases and therefore water uptake from the loop of henle also decreases.  Increased amounts of all three ions are lost as a result.   

Loop diuretics as the name suggests work on the loop of henle.  Specifically on the [[Reabsorption and Secretion Along the Loop of Henle - Anatomy & Physiology#Thick ascending limb|thick ascending limb]] where they inhibit the activity of the sodium/potassium/2-chloride symporter.  As a result the hypertonicity of the medulla decreases and therefore water uptake from the loop of henle also decreases.  Increased amounts of all three ions are lost as a result.   

As well as reducing the reuptake of water they also increase renal blood flow via [[The Effects of Nitrous Oxide and Prostaglandins on GFR - Anatomy & Physiology|prostaglandin mediated vasodilation]].  This increases filtration to help lessen fluid retention.

As well as reducing the reuptake of water they also increase renal blood flow via [[Glomerular Filtration Rate#Nitrous Oxide and Prostaglandins|prostaglandin mediated vasodilation]].  This increases filtration to help lessen fluid retention.

Loop diuretics tend to be bound to plasma protein and therefore are not filtered.  They enter the tubule via secretion by the [[Reabsorption and Secretion Along the Proximal Tubule - Anatomy & Physiology#Primary Active Secretion - Organic Acids and Bases|organic acid transport mechanisms]].

Loop diuretics tend to be bound to plasma protein and therefore are not filtered.  They enter the tubule via secretion by the [[Reabsorption and Secretion Along the Proximal Tubule - Anatomy & Physiology#Primary Active Secretion - Organic Acids and Bases|organic acid transport mechanisms]].