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Liver - Anatomy & Physiology (view source)
Revision as of 18:11, 10 December 2010
, 18:11, 10 December 2010no edit summary
See [[Avian Liver - Anatomy & Physiology|avian liver]]
See [[Avian Liver - Anatomy & Physiology|avian liver]]
==Histology==
[[Image:Lobule Histology.jpg|thumb|right|150px|Liver Lobule Histology - Copyright RVC 2008]]
*Connective tissue capsule around each lobule
*Thin mesothelium covers connective tissue layer
*The larger liver cells are called lobules
**Each lobule contains an opening for the central vein and contains portal areas
**Lobules composed of liver cords called hepatocytes
**Sinusoids present between hepatocytes containing red blood cells
*Portal area present in lobules
**Hepatic artery- thick walls, small diameter
**Hepatic vein- thin walls, large and irregular shape
**Bile ducts- cuboidal or columnar epithelium
**Lymphatics- small and delicate
[[Image:Portal Triad Histology.jpg|thumb|right|150px|Portal Triad Histology in a Lobule- Copyright RVC 2008]]
*Hepatocytes are the smaller liver cells in the lobules
**Contain glycogen granules
**Stain pink as are eosinophilic
**Spherical nucleus
**Forms cords called branching plates (lamellae)
**Upper and lower margins are tight junctions
**3 functioning surfaces
***Adjacent to sinusoid contains microvilli
***Between adjacent cells are smooth
***Adjacent cells have short microvilli, membranes diverge, explanded intracellular spaces and bile canaliculi
*Kupfer macrophages present near the lining of the sinusoids
===Acinus===
*the smallest functional unit of the [[Liver - Anatomy & Physiology|liver]] - this unit stresses the dependence of the [[Liver - Anatomy & Physiology|liver]] on its afferent blood vessels and efferent bile ducts
*a roughly diamond shaped parenchymal mass surrounding and supplied by the portal area
*consists of 3 zones:
**Zone 1 - periportal (centroacinar), around the portal areas
**Zone 2 - midzonal
**Zone 3 - centrilobular (periacinar), bordering the hepatic venules
NB: blood enters from Zone 1 to Zone 3 and thus becomes less and less oxygenated
==Links==
==Links==
'''Test yourself with the [[Liver - Anatomy & Physiology - Flashcards|Liver & Gall Bladder Flashcards]]'''
'''Test yourself with the [[Liver - Anatomy & Physiology - Flashcards|Liver & Gall Bladder Flashcards]]'''
'''Click here for information on [[:Category:Liver - Pathology|pathology of the Liver]]'''
'''Click here for information on [[:Category:Liver - Pathology|pathology of the Liver]]'''