Changes

*decreased chloride delivery to the macula densa is detected by chemoreceptors - a drop in glomerular filtration rate (GFR) detected as a drop in chloride presented at the macula densa leads to increased reabsorption in the proximal convoluted tubule.

*decreased chloride delivery to the macula densa is detected by chemoreceptors - a drop in glomerular filtration rate (GFR) detected as a drop in chloride presented at the macula densa leads to increased reabsorption in the proximal convoluted tubule.

Renin then leads to the [[Renin_Angiotensin_Aldosterone_System#The_System|cleavage]] of circulating Angiotensinogen (produced by the liver) to angiotensin I, and then [[Angiotensin Converting Enzyme (ACE) - Anatomy & Physiology|angiontensin converting enzyme (ACE)]] catalyses the production of angiotensin II from angiotensin I - this occurs mainly in the lungs. ACE is bound to endothelial cells throughout the vascular system. Angiotensin II acts as a stimulus to [[Aldosterone|aldosterone]] release from the zona glomerulosa of the [[Adrenal Glands - Anatomy & Physiology|adrenal cortex]], which in turn leads to sodium and water retention in the cortical collecting duct of the renal tubule.

Renin then leads to the [[Renin_Angiotensin_Aldosterone_System#The_System|cleavage]] of circulating Angiotensinogen (produced by the liver) to angiotensin I, and then [[Angiotensin Converting Enzyme|angiontensin converting enzyme (ACE)]] catalyses the production of angiotensin II from angiotensin I - this occurs mainly in the lungs. ACE is bound to endothelial cells throughout the vascular system. Angiotensin II acts as a stimulus to [[Aldosterone|aldosterone]] release from the zona glomerulosa of the [[Adrenal Glands - Anatomy & Physiology|adrenal cortex]], which in turn leads to sodium and water retention in the cortical collecting duct of the renal tubule.

'''NOTE''' This system is responsible for the long-term maintenance of blood pressure, but is also activated very rapidly in the presence of hypotension.

'''NOTE''' This system is responsible for the long-term maintenance of blood pressure, but is also activated very rapidly in the presence of hypotension.