Very severe systemic disease early in life / or in utero may result in severe discoloration or pitting of teeth due to effect on [[Enamel|enamel]] formation. (e.g. [[Canine Distemper Virus|distemper in dog]]) | Very severe systemic disease early in life / or in utero may result in severe discoloration or pitting of teeth due to effect on [[Enamel|enamel]] formation. (e.g. [[Canine Distemper Virus|distemper in dog]]) |