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Bones - Anatomy & Physiology (view source)
Revision as of 15:30, 6 January 2011
, 15:30, 6 January 2011→Wolff's Law
Cells use strain as a stimulus to adjust mass and architecture according to load. Resorption and osteogenesis happen concurrently to maintain bone integrity. This is mediated by two hormones:
Cells use strain as a stimulus to adjust mass and architecture according to load. Resorption and osteogenesis happen concurrently to maintain bone integrity. This is mediated by two hormones:
1. '''Parathyroid hormone (PTH)'''
1. [[Calcium#Parathyroid Hormone (PTH)|'''Parathyroid hormone (PTH)''']]
Produced by <u>chief cells in the parathyroid glands</u> in response to <u>decreased</u> serum calcium. In response, osteoclasts increase in number and resorb mineralised matrix to increase Ca in blood.
Produced by <u>chief cells in the parathyroid glands</u> in response to <u>decreased</u> serum calcium. In response, osteoclasts increase in number and resorb mineralised matrix to increase Ca in blood.
2. '''Calcitonin'''
2. [[Calcium#Calcitonin|'''Calcitonin''']]
Produced by <u>C-cells in the thyroid glands</u> in response to <u>increased</u> serum calcium. Inhibits osteoclasts.
Produced by <u>C-cells in the thyroid glands</u> in response to <u>increased</u> serum calcium. Inhibits osteoclasts.