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− | <p>''Shortened to IgD''</p>
| + | ==Overview== |
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| [[Image:LH IgD.png|thumb|250px|right|'''IgD''']] | | [[Image:LH IgD.png|thumb|250px|right|'''IgD''']] |
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| [[Image:IgD.jpg|thumb|right|250px|IgD - B. Catchpole, RVC 2008]] | | [[Image:IgD.jpg|thumb|right|250px|IgD - B. Catchpole, RVC 2008]] |
− | | + | ''Shortened to IgD''. |
− | ==Overview==
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| IgD is present in ruminants, pigs, dogs and rodents but has not been identified in horses, cats, rabbits and chickens. It is mainly expressed on the surface of B-cells i.e. it is never secreted. | | IgD is present in ruminants, pigs, dogs and rodents but has not been identified in horses, cats, rabbits and chickens. It is mainly expressed on the surface of B-cells i.e. it is never secreted. |
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| ==Structure== | | ==Structure== |
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− | IgD is Y-shaped. In rodents, it has two heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds. | + | IgD is Y-shaped. In rodents, it has two δ heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds. |
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| ==Function== | | ==Function== |
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− | IgD is only expressed in association with [[IgM]]. It is important in B-cell development. | + | IgD is only expressed in association with [[IgM]]. It is thought to be important in B-cell development, although it has been shown in δ chain knockout mice (so they have no functional IgD) do not have any noticeable defects in immune function. |
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| + | <p> Interestingly IgD serum levels increase in allergic reactions, although it is not known why this is.</p> |
− | <center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center> | + | |
| + | ==Links== |
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| + | [[Immunoglobulins|Immunoglobulins]] |
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| + | [[Immunoglobulin A|Immunoglobulin A]] |
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| + | [[Immunoglobulin E|Immunoglobulin E]] |
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| + | [[Immunoglobulin G|Immunoglobulin G]] |
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| + | [[Immunoglobulin M|Immunoglobulin M]] |
| + | <br><br> |
| + | {{Jim Bee 2007}} |
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| + | {{OpenPages}} |
| [[Category:Immunoglobulins]] | | [[Category:Immunoglobulins]] |
− | [[Category:Image Review]] | + | [[Category:A&P Done]] |
− | [[Category:To Do - A&P]]
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