Changes

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Within the '''sinusoidal membrane''', Na/K ATPase maintains a –35mV charge which drives several transport mechanisms. The Na/H+ pump drives protons out of the cell whilst HCO3- is exhanged for Na+ facilitating the entry of bicarbonate. Therefore active concentration of bile salts or acids is Na+ dependent.

Within the '''sinusoidal membrane''', Na/K ATPase maintains a –35mV charge which drives several transport mechanisms. The Na/H+ pump drives protons out of the cell whilst HCO3- is exhanged for Na+ facilitating the entry of bicarbonate. Therefore active concentration of bile salts or acids is Na+ dependent and transport from the plasma into hepatocytes is mediated by the sodium taurocholate cotransporter.Other non-conjugated bile salt (cholate) and lipophilic albimin-bound compounds are transported from plasma into hepatocytes via a sodium-independent transporter. Bile salts are the most abundant solutes in bile

 

 

**Canalicular membrane

**Canalicular membrane

***Rate limiting step

***Rate limiting step