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Hydropic Degeneration (view source)
Revision as of 14:21, 15 February 2011
, 14:21, 15 February 2011Created page with "* Hydropic degeneration often indicates severe cellular damage due to viruses. ** Is a more severe or advanced form of cellular swelling. * There are two types of hydropic degene..."
* Hydropic degeneration often indicates severe cellular damage due to viruses.
** Is a more severe or advanced form of cellular swelling.
* There are two types of hydropic degeneration, in which:
*# The cells may swell up like a balloon prior to their destruction.
*#* '''Ballooning Degeneration'''
*# There is a discrete bleb (vacuole) of fluid within the cytoplasm.
*#* '''Vacuolar Degeneration'''
===Ballooning Degeneration===
* May occur in a variety of conditions.
** Is particularly seen in viral conditions of epithelial tissue.
* [[Foot and Mouth Disease|Foot and Mouth Disease]] is the best example.
** Foot and Mouth virus attacks the stratum spinosum of the epithelium of the [[Tongue - Anatomy & Physiology|tongue]] and feet.
** Affected cells balloon up with water containing the replicating virus, swelling until they burst.
*** The fluid contained in the cells then forms microvesicles (blisters) in the stratum spinosum.
**** Blisters may later burst, shedding vast quantities of the virus.
** On bursting, the edges of the erosions look ragged.
*** Within weeks, the germinal epithelium at the base of the erosion regenerates the epithelium, leaving no trace of a scar.
===Vacuolar Degeneration===
* In vacuolar degeneration, excess water is transferred to the endoplasmic reticulum (ER).
* The ER swells and eventually fragments.
** A fluid vacuole remains in the cytoplasm.
* Commonly occurs in cells that are very metabolically active and have well developed pumping mechanisms.
** E.g. as the hepatocyte, renal tubular epithelium and pancreatic acinar cell.
[[Category:Degenerations and Infiltrations]]
** Is a more severe or advanced form of cellular swelling.
* There are two types of hydropic degeneration, in which:
*# The cells may swell up like a balloon prior to their destruction.
*#* '''Ballooning Degeneration'''
*# There is a discrete bleb (vacuole) of fluid within the cytoplasm.
*#* '''Vacuolar Degeneration'''
===Ballooning Degeneration===
* May occur in a variety of conditions.
** Is particularly seen in viral conditions of epithelial tissue.
* [[Foot and Mouth Disease|Foot and Mouth Disease]] is the best example.
** Foot and Mouth virus attacks the stratum spinosum of the epithelium of the [[Tongue - Anatomy & Physiology|tongue]] and feet.
** Affected cells balloon up with water containing the replicating virus, swelling until they burst.
*** The fluid contained in the cells then forms microvesicles (blisters) in the stratum spinosum.
**** Blisters may later burst, shedding vast quantities of the virus.
** On bursting, the edges of the erosions look ragged.
*** Within weeks, the germinal epithelium at the base of the erosion regenerates the epithelium, leaving no trace of a scar.
===Vacuolar Degeneration===
* In vacuolar degeneration, excess water is transferred to the endoplasmic reticulum (ER).
* The ER swells and eventually fragments.
** A fluid vacuole remains in the cytoplasm.
* Commonly occurs in cells that are very metabolically active and have well developed pumping mechanisms.
** E.g. as the hepatocyte, renal tubular epithelium and pancreatic acinar cell.
[[Category:Degenerations and Infiltrations]]