Line 1: |
Line 1: |
| + | ==Introduction== |
| Hyalisation of muscle fibrils of skeletal, intercostal, diaphragmatic and cardiac muscles. Histologically there is '''[[Zenker Degeneration - Pathology|Zenker degeneration]]''' and occasionally also '''[[Myocardial Mineralisation|dystrophic calcification]]'''. | | Hyalisation of muscle fibrils of skeletal, intercostal, diaphragmatic and cardiac muscles. Histologically there is '''[[Zenker Degeneration - Pathology|Zenker degeneration]]''' and occasionally also '''[[Myocardial Mineralisation|dystrophic calcification]]'''. |
| | | |
Line 10: |
Line 11: |
| | | |
| Also associated with a diet over-rich in unsaturated fatty acids seen in pigs (Vitamin E/Selenium unavailable as used up by the unsaturated fats). | | Also associated with a diet over-rich in unsaturated fatty acids seen in pigs (Vitamin E/Selenium unavailable as used up by the unsaturated fats). |
| + | |
| + | |
| + | * The term "hyaline degeneration" is applied to several types of degeneration or infiltration. |
| + | ** "Hyaline" is a descriptive term meaning "glassy". |
| + | *** Used in pathology when structureless material appears in section, and stains red with eosin |
| + | **** Describes a variety of conditions in which structureless materials are present. |
| + | * Is applied to both extra- and intra-cellular degenerations/ infiltrations. ** '''Extracellular''' |
| + | *** Protein hyaline casts in the renal tubules. |
| + | **** From excessive protein passing through glomerulus. |
| + | **** When fresh urine is examined under the microscope, casts may be seen as elongated glassy tubes. |
| + | *** Hyaline membranes |
| + | **** Proteinaceous effusions into pulmonary alveoli |
| + | **** Prevent gaseous exchange. ** '''Intracellular''' |
| + | *** Hyaline degeneration of skeletal muscle. |
| + | **** In vitamin E/ selenium deficiency. |
| + | * There are two forms of hyaline degeneration that deserve their own mention. |
| + | ** Fibrinoid degeneration. |
| + | ** Amyloid infiltration. |
| + | |
| + | ===Fibrinoid Degeneration=== |
| + | |
| + | * Fibrinoid degeneration features a material which is fibrin-like. |
| + | * Is essentially a focal death of cells in the walls of small blood vessels (usually arterioles). |
| + | ** Parts of the vessel wall become replaced by a granular material. |
| + | *** Pinkish-red (i.e. eosin-staining). |
| + | *** Has some of the appearance and staining properties of fibrin. |
| + | *** Consists partly of degenerated muscle and elastic fibres, and partly of an increased amount of protein ground substance around the degenerated fibres. |
| + | *** Looks like a red smudge in the vessel wall when viewed histologically. |
| + | * The presence of the fibrin-like material may suggest |
| + | ** A local hypersensitivity reaction |
| + | ** Hypertension |
| + | |
| + | ===Amyloidosis=== |
| + | |
| + | * Also known as amyloid infiltration |
| + | * Deposition of a proteinaceous hyaline substance in extracellular sites. |
| + | ** Sites of deposition vary with species. |
| + | * The kidney is a common site of deposition. |
| + | ** Amyloid is deposited under the capillary endothelium and progressively increases in volume. |
| + | * There are various categories of amyloid. |
| + | ** Is essentially an abnormal protein produced in the body |
| + | ** In most cases, it is produced in response to sustained antigenic stimulation caused by a chronic suppurative process. |
| + | *** E.g. a foot abscess, mastitis. |
| + | * Amyloid is a relatively inert substance. |
| + | ** When it accumulates, it is not easily removed. |
| + | |
| + | |
| | | |
| ==Test yourself with the Mycocardial Pathology Flashcards== | | ==Test yourself with the Mycocardial Pathology Flashcards== |
| | | |
| [[Myocardial_Pathology_Flashcards_-_Pathology|Myocardial Pathology Flashcards]] | | [[Myocardial_Pathology_Flashcards_-_Pathology|Myocardial Pathology Flashcards]] |
| + | |
| + | |
| + | |
| + | |
| + | [[Category:Degenerations and Infiltrations]] |
| | | |
| [[Category:Cardiovascular_System_-_Metabolic_Pathology]][[Category:Myocardial_Pathology]] | | [[Category:Cardiovascular_System_-_Metabolic_Pathology]][[Category:Myocardial_Pathology]] |