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Glycogen Infiltration (view source)
Revision as of 14:26, 15 February 2011
, 14:26, 15 February 2011Created page with "* Glycogen is normally present in substantial amounts in the liver and muscle. ** Is a readily utilisable source of energy. * Moderate glycogen i..."
* Glycogen is normally present in substantial amounts in the [[Liver - Anatomy & Physiology|liver]] and muscle.
** Is a readily utilisable source of energy.
* Moderate glycogen infiltration in the [[Liver - Anatomy & Physiology|liver]]:
** Grossly - doesn't have much effect.
** Histologically - shows up as foamy cytoplasmic vacuoles, similar to that of fat.
* Some conditions may result in an increase in glycogen deposits.
** [[DM|'''Diabetes mellitus''']]
*** Gives an increase in hepatic glycogen stores.
*** May be overshadowed by the increased fat in the hepatocytes, and therefore difficult to see.
**** Renal tubular deposits are more easily observed.
** '''Excessive glucocorticoids'''
*** Could be due to:
**** Hyperadrenocortism
**** Animals being maintained on glucocorticoid therapy over a long period of time.
***** Has more dramatic effect.
*** Huge amounts of glycogen infiltration.
**** [[Liver - Anatomy & Physiology|Liver]] appears larger and paler.
**** Vacuoles may be so extensive that the rest of the cytoplasm appear as pink strands passing from the nucleus to the plasma membrane.
***** A "feathery appearance" or "web-like effect".
** '''Glycogen storage diseases'''
*** Due to an inherited deficiency of an enzyme required for the breakdown of glycogen to glucose.
**** Cells continuously accumulate glycogen.
*** Seen in all tissues of the body but exerts its major effect in the CNS.
* Selective staining must be employed to distinguish glycogen vacuoles from fatty vacuoles in the [[Liver - Anatomy & Physiology|liver]].
** Alcohol fixation is preferred.
** Best's Carmine is the commonly used stain.
*** Stains the intracellular glycogen red.
[[Category:Degenerations and Infiltrations]]
** Is a readily utilisable source of energy.
* Moderate glycogen infiltration in the [[Liver - Anatomy & Physiology|liver]]:
** Grossly - doesn't have much effect.
** Histologically - shows up as foamy cytoplasmic vacuoles, similar to that of fat.
* Some conditions may result in an increase in glycogen deposits.
** [[DM|'''Diabetes mellitus''']]
*** Gives an increase in hepatic glycogen stores.
*** May be overshadowed by the increased fat in the hepatocytes, and therefore difficult to see.
**** Renal tubular deposits are more easily observed.
** '''Excessive glucocorticoids'''
*** Could be due to:
**** Hyperadrenocortism
**** Animals being maintained on glucocorticoid therapy over a long period of time.
***** Has more dramatic effect.
*** Huge amounts of glycogen infiltration.
**** [[Liver - Anatomy & Physiology|Liver]] appears larger and paler.
**** Vacuoles may be so extensive that the rest of the cytoplasm appear as pink strands passing from the nucleus to the plasma membrane.
***** A "feathery appearance" or "web-like effect".
** '''Glycogen storage diseases'''
*** Due to an inherited deficiency of an enzyme required for the breakdown of glycogen to glucose.
**** Cells continuously accumulate glycogen.
*** Seen in all tissues of the body but exerts its major effect in the CNS.
* Selective staining must be employed to distinguish glycogen vacuoles from fatty vacuoles in the [[Liver - Anatomy & Physiology|liver]].
** Alcohol fixation is preferred.
** Best's Carmine is the commonly used stain.
*** Stains the intracellular glycogen red.
[[Category:Degenerations and Infiltrations]]