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Created page with "right|thumb|100px|<small><center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center></small> [[Image:Bronchiect..."
[[Image:Bronchiectasis.jpg|right|thumb|100px|<small><center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
[[Image:Bronchiectasis micro.jpg|right|thumb|100px|<small><center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
*Permanent, abnormal saccular or cylindrical dilation of bronchi
*Accumulation of exudate within the lumen and partial rupture of bronchial walls
*Sequel to [[Bronchi and Bronchioles Inflammatory - Pathology#Chronic bronchitis|chronic bronchitis]] as result of an unresolved persistent [[Lungs Inflammatory - Pathology#Bronchopneumonia|bronchopneumonia]]
*Chronic inflammation within the bronchial mucosa and wall -> release of proteolytic enzymes from [[Neutrophils|neutrophils]] and macrophages -> destruction of supporting structures in the bronchial walls (eg: cartilage, connective tissue) -> weakens the bronchial walls and damages lining mucosal epithelial cells and their cilia (damage to mucociliary escalator)
*[[Lungs Ventilation - Pathology#Atelectasis|Atelectasis]] in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration
*The weakened bronchial walls are less able to 'resist' the negative pressure and therefore dilate excessively.
*With time this dilation becomes permanent as a viscous cycle of exudate pooling in the lumen and increased contact of the bronchial walls with the leukocytes further weakens the bronchial walls.
*Most severe in cattle (complete lobular septation and lack of collateral ventilation), least severe in dogs (good colateral ventilation), also seen in sheep, goats and pigs
*In very severe cases, the bronchial wall is completely destroyed and unrecognisable - an abscess
==Test yourself with the Bronchi and Bronchioles Pathology Flashcards==
[[Bronchi_and_Bronchioles_Flashcards_-_Pathology|Bronchi and Bronchioles Pathology Flashcards]]
[[Category:Bronchi and Bronchioles - Pathology]]
[[Category:Respiratory System - Inflammatory Pathology]]
[[Image:Bronchiectasis micro.jpg|right|thumb|100px|<small><center>Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
*Permanent, abnormal saccular or cylindrical dilation of bronchi
*Accumulation of exudate within the lumen and partial rupture of bronchial walls
*Sequel to [[Bronchi and Bronchioles Inflammatory - Pathology#Chronic bronchitis|chronic bronchitis]] as result of an unresolved persistent [[Lungs Inflammatory - Pathology#Bronchopneumonia|bronchopneumonia]]
*Chronic inflammation within the bronchial mucosa and wall -> release of proteolytic enzymes from [[Neutrophils|neutrophils]] and macrophages -> destruction of supporting structures in the bronchial walls (eg: cartilage, connective tissue) -> weakens the bronchial walls and damages lining mucosal epithelial cells and their cilia (damage to mucociliary escalator)
*[[Lungs Ventilation - Pathology#Atelectasis|Atelectasis]] in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration
*The weakened bronchial walls are less able to 'resist' the negative pressure and therefore dilate excessively.
*With time this dilation becomes permanent as a viscous cycle of exudate pooling in the lumen and increased contact of the bronchial walls with the leukocytes further weakens the bronchial walls.
*Most severe in cattle (complete lobular septation and lack of collateral ventilation), least severe in dogs (good colateral ventilation), also seen in sheep, goats and pigs
*In very severe cases, the bronchial wall is completely destroyed and unrecognisable - an abscess
==Test yourself with the Bronchi and Bronchioles Pathology Flashcards==
[[Bronchi_and_Bronchioles_Flashcards_-_Pathology|Bronchi and Bronchioles Pathology Flashcards]]
[[Category:Bronchi and Bronchioles - Pathology]]
[[Category:Respiratory System - Inflammatory Pathology]]