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Type IV Hypersensitivity (view source)
Revision as of 16:20, 22 February 2011
, 16:20, 22 February 2011no edit summary
* It is used for TB testing cattle; the antigen is purified protein derivative-PPD from [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']].
* It is used for TB testing cattle; the antigen is purified protein derivative-PPD from [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']].
* Presently in the UK the animal is culled if it has a positive skin reaction.
* Presently in the UK the animal is culled if it has a positive skin reaction.
==From Pathology==
*Delayed hypersensitivity
*Haptens bind to carrier proteins (mainly epidermal)
*Mediated by sensitised [[T cell differentiation|T-cells]] -> release cytokines +/- recruit lymphocytes
*Used in diagnosis of tuberculosis, histoplasmosis and coccidiomycosis
*Perivascular mononuclear cell accumulation
[[Category:Hypersensitivity]]
[[Category:Hypersensitivity]]