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| | ===[[Systemic Lupus Erythematosus]]=== | | ===[[Systemic Lupus Erythematosus]]=== |
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| − | *'''Systemic (SLE)'''
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| − | **Multiple organs involved
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| − | **Cats, dogs, horses
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| − | **Immune dysregulation:
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| − | ***Damaged T-cell suppressor function, either primary deficiency or antibody mediated
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| − | ***Cytokine dysregulation
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| − | ***Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity
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| − | **Lesions localised or generalised
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| − | **Erythema, alopecia, depigmentation, crusting and scaling, ulceration
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| − | **Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration
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| − | *'''Discoid'''
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| − | **Milder variant of systemic
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| − | **Depigmentation, erythema, scaling, erosions, ulceration, crusting
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| − | **Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area
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| − | **Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment
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| − | [[Category:Integumentary System - Autoimmune Reactions]]
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| | ===[[Pemphigus]]=== | | ===[[Pemphigus]]=== |