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− | | + | ==Introduction== |
− | ==Description== | |
| Glucagonomas are very rare tumours of the alpha cells of the pancreatic islets of Langerhans that produce the hormone glucagon without appropriate regulation. The excessive secretion of glucogon is a form of topic paraneoplastic syndrome. The disease has been reported in approximately ten dogs and it is therefore extremely rare. | | Glucagonomas are very rare tumours of the alpha cells of the pancreatic islets of Langerhans that produce the hormone glucagon without appropriate regulation. The excessive secretion of glucogon is a form of topic paraneoplastic syndrome. The disease has been reported in approximately ten dogs and it is therefore extremely rare. |
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− | As in humans, glucagonoma is characterised by the formation of skin lesions collectively described as '''necrolytic migratory erythema''' (NME)<ref>Byrne KP. '''Metabolic epidermal necrosis-hepatocutaneous syndrome.''' ''Vet Clin North Am Small Anim Pract. 1999 Nov;29(6):1337-55.''</ref>, a syndrome which is observed much more commonly in dogs with liver failure when it is termed [[Endocrine effects on the skin - Pathology#Superficial Necrolytic Dermatopathy|'''hepataocutaneous syndrome''']]. Glucagonoma accounts for approximately ten percent of cases of NME. Dogs with glucagonoma frequently show signs of [[Diabetes Mellitus|diabetes mellitus]] as glucagon is antagonistic to insulin. | + | As in humans, glucagonoma is characterised by the formation of skin lesions collectively described as [[Hepatocutaneous Syndrome|'''necrolytic migratory erythema''' (NME)]]<ref>Byrne KP. '''Metabolic epidermal necrosis-hepatocutaneous syndrome.''' ''Vet Clin North Am Small Anim Pract. 1999 Nov;29(6):1337-55.''</ref>, a syndrome which is observed much more commonly in dogs with liver failure when it is termed [[Endocrine effects on the skin - Pathology#Superficial Necrolytic Dermatopathy|'''hepataocutaneous syndrome''']]. Glucagonoma accounts for approximately ten percent of cases of NME. Dogs with glucagonoma frequently show signs of [[Diabetes Mellitus|diabetes mellitus]] as glucagon is antagonistic to insulin. |
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| ==Signalment== | | ==Signalment== |
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| The prognosis is generally poor as the tumour has usually metastasised by the time it is diagnosed. | | The prognosis is generally poor as the tumour has usually metastasised by the time it is diagnosed. |
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− | ==Literature Search==
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| + | |literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=Glucagonoma&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&x=76&y=6&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Glucagonoma publications] |
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− | Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
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− | [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=Glucagonoma&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&x=76&y=6&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Glucagonoma publications] | |
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| ==References== | | ==References== |
| <references/> | | <references/> |
| Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine (6th edition, volume 2)''' ''Elsevier Saunders'' | | Ettinger, S.J, Feldman, E.C. (2005) '''Textbook of Veterinary Internal Medicine (6th edition, volume 2)''' ''Elsevier Saunders'' |
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| [[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]] | | [[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]][[Category:Endocrine_System_-_Pathology]] |