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Pancreatic Atrophy, Exocrine (view source)
Revision as of 17:48, 24 February 2011
, 17:48, 24 February 2011no edit summary
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*[[Exocrine Pancreatic Atrophy in GSDs and Rough Coated Collies|Further Study]][[Category:Pancreas - Degenerative Pathology ]]+
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*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
*Low serum trypsin-like immunoreactivity is an early, preclinical diagnostic test for EPI
−<big>Extra information for Exocrine Pancreatic Atrophy
+Exocrine pancreatic atrophy in GSDs and rough coated collies: an end result of lymphocytic pancreatitis. Wiberg ME et al. Vet Path (1999) 36 530-41</big>
+*Histological changes in EPI dogs
+*Histological changes in the subclinical pancreas (ie; just TLI):
+*Patchy areas of normal and abnormal exocrine parenchyma
+*Consistently a marked lymphoid infiltrate (lesser numbers of plasma cells seen, occasional eosinophils), starting in the border zone with gradual loss of the pancreatic parenchyma
+*Mainly CD3+ T cells, with fewer CD3+ lymphocytes.
+*Some lymphoid follicles (mainly B cells) scattered throughout.
+*No associated increase in fibrous connective tissue
+*Some intra-acinar lymphocytes seen
+*As tissue destruction continued, ductal structures became more obvious
+*Apoptosis seen in the acini often in normal looking acini.
+*Ultrastructure
+**Degenerative changes in acinar cells – dilation of rER, swelling of mitochondria, nuclear pyknosis, aptotitic bodies
+*Histology of clinical EPI:
+**Totally atrophied exocrine pancreas
+**Some dogs had areas of normal acinar structures
+**Little inflammation in the border zone
+**Most of the remaining exocrine pancreas was disorganized, prominent ducts, increased amounts of adipose tissue.
+**Slight increase in fibrous tissue compared to subclinical phase, but replacement with fat was more prominent than fibrosis.
+**No ductular epithelial hyperplasia evident
+*Ultrastructure
+**Often no remaining acinar cells
+*Suggests and immune-mediated destruction - ?hereditary
+*Islet cells usually well preserved in the atrophied pancreas.
+[[Category:Pancreas - Degenerative Pathology ]]
[[Category:Pancreatic Diseases - Dog]]
[[Category:Pancreatic Diseases - Dog]]
[[Category:To_Do_-_Clinical]]
[[Category:To_Do_-_Clinical]]