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*Most infections are exacerbated by host response
 
*Most infections are exacerbated by host response
 
*Pathogenesis:
 
*Pathogenesis:
**Prostaglandin and cytokines stimulate [[Bones - normal#Normal structure|osteoclastic]] bone resorption
+
**Prostaglandin and cytokines stimulate [[Bones - Anatomy & Physiology|osteoclastic]] bone resorption
 
**Blood vessel occlusion and tissue necrosis -> lack of removal of agent and cartilage -> cartilage thickening + persistance of infection
 
**Blood vessel occlusion and tissue necrosis -> lack of removal of agent and cartilage -> cartilage thickening + persistance of infection
 
*Affected area may be surrounded by fibrous inflammatory tissue
 
*Affected area may be surrounded by fibrous inflammatory tissue
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