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| − | ===[[Hypovitaminosis A]]===
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| − | ===[[Hypervitaminosis A]]===
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| − | ===Hypervitaminosis D===
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| − | *May be of dietary or iatrogenic origin (has narrow safety margin)
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| − | *Key features are hypercalcaemia with metastatic calcification of soft tissues
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| − | *'''Acute poisoning'''
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| − | **In dogs and cats often from rodenticides containing cholecalciferol
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| − | **Grossly:
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| − | ***Gastrointestinal haemorrhage
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| − | ***Foci of [[Myocardial Mineralisation|myocardial discoloration]]
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| − | **Microscopically:
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| − | ***Mucosal haemorrhage
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| − | ***Necrosis of crypts
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| − | ***Focal myocardial necrosis
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| − | ***Mineralisation of intestinal mucosa, [[Arterial Calcification#Medial calcification|blood vessel walls]], [[Pulmonary Calcification|lungs]] and kidneys
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| − | *'''Chronic poisoning'''
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| − | **Grossly:
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| − | ***Intense [[Bones - Anatomy & Physiology|osteoclastic activity]] -> active resorption of bone, especially [[Bones - Anatomy & Physiology|trabecular]]
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| − | **Microscopically:
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| − | ***Excessive production of [[Bones - Anatomy & Physiology|osteoid]] - appears both eosinophilic and basophilic in different places
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| − | ***Marrow cavity may be obliterated
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| − | ***Mineralisation of soft tissues, especially [[Arterial Calcification|blood vessel walls]]
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| − | **Due to inhibition of [[Calcium|Parathyroid Hormone (PTH)|PTH]] and increase of [[Calcium#Calcitonin|calcitonin]]
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| − | [[Category:Bones - Metabolic Pathology]]
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| − | [[Category:Toxicology]]
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| − | ===Fluorine poisoning===
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| − | *F is widespread in nature
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| − | *Pastures may be contaminated by industrial processes (e.g. brick manufacture)
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| − | *'''Acute poisoning''':
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| − | **Gastroenteritis
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| − | **Nephrosis
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| − | *'''Chronic poisoning''':
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| − | **''Dental abnormalities''
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| − | ***Intoxication during teeth development
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| − | ***Foci of poor enamel formation - yellow, dark brown/black, chalky
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| − | ***Irregular wear of teeth, chip easily
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| − | **''Osteodystrophy = Fluorosis''
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| − | ***Generalised skeletal disturbance
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| − | ***Most affected are metatarsals and mandibles
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| − | ***Periosteal hyperostosis + endosteal bone resorption -> thickened bones with enlarged marrow cavities
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| − | [[Category:Bones - Metabolic Pathology]]
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| − | [[Category:Toxicology]]
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| − | ===Lead poisoning===
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| − | *Lead can bind to mineral portion of bone and cartilage
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| − | *In young animals ingesting large dose at once
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| − | ** -> Lead induced malfunction of osteoclasts
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| − | ** -> Transverse band of increased density on radiographs of metaphysis = "lead line" = [[Retention of Elongated Primary Trabeculae|growth retardation lattice]]
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| − | [[Category:Bones - Metabolic Pathology]]
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| − | [[Category:Toxicology]]
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| − | [[Category:Musculoskeletal System - Pathology]]
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